The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines

W.-   W.   Yang; L.-   F.   Cun; Y.-   G.   Zhi; A.-   Q.   Mi; Y.-   Z.   Jiang; L.-   Z.   Gong

doi:10.2174/157017805774296939

Abstract

The use of easily accessible N-monosubstituted 1,2-diphenyl-2-aminoethanols as ligands to promote the asymmetric addition of diethylzinc to alkyl- and arylimines generated in situ from the precursors provided optically active N-diphenylphosphinylamines with enantioselectivities of up to 96% ee.

Keywords: asymmetric catalysis, amino alcohols, diethylzinc addition, imines

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Letters in Organic Chemistry

Title: The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines

Volume: 2 Issue: 7

Author(s): W.- W. Yang, L.- F. Cun, Y.- G. Zhi, A.- Q. Mi, Y.- Z. Jiang and L.- Z. Gong

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Keywords: asymmetric catalysis, amino alcohols, diethylzinc addition, imines

Abstract: The use of easily accessible N-monosubstituted 1,2-diphenyl-2-aminoethanols as ligands to promote the asymmetric addition of diethylzinc to alkyl- and arylimines generated in situ from the precursors provided optically active N-diphenylphosphinylamines with enantioselectivities of up to 96% ee.

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Yang W. W.-, Cun F. L.-, Zhi G. Y.-, Mi Q. A.-, Jiang Z. Y.- and Gong Z. L.-, The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines, Letters in Organic Chemistry 2005; 2 (7) . https://dx.doi.org/10.2174/157017805774296939