Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function]

E.      Rozners

doi:10.2174/1570178054640714

Abstract

Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non- Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

Keywords: dna, heterocyclic bases, watson-crick-like hydrogen-bonding, epimerization, hybridization, nucleobases, hydrophobic base

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Letters in Organic Chemistry

Title: Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function]

Volume: 2 Issue: 6

Author(s): E. Rozners

Affiliation:

Keywords: dna, heterocyclic bases, watson-crick-like hydrogen-bonding, epimerization, hybridization, nucleobases, hydrophobic base

Abstract: Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non- Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

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Rozners E., Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function], Letters in Organic Chemistry 2005; 2 (6) . https://dx.doi.org/10.2174/1570178054640714