Recent Advances in the Synthesis of C-oligosaccharides

Xuejun      Yuan; Robert   J.   Linhardt

doi:10.2174/156802605774643033

Abstract

This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.

Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal

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Current Topics in Medicinal Chemistry

Title: Recent Advances in the Synthesis of C-oligosaccharides

Volume: 5 Issue: 14

Author(s): Xuejun Yuan and Robert J. Linhardt

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Keywords: Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal

Abstract: This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.

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Yuan Xuejun and Linhardt J. Robert, Recent Advances in the Synthesis of C-oligosaccharides, Current Topics in Medicinal Chemistry 2005; 5 (14) . https://dx.doi.org/10.2174/156802605774643033