Recent Advances in Aryl C-Glycoside Synthesis

Title: Recent Advances in Aryl C-Glycoside Synthesis

Volume: 5 Issue: 14

Author(s): David Y. W. Lee and Minsheng He

Affiliation:

Keywords: de-O-methylation, Glycosyl halides, Lactones, Cyclization, intramolecular tether approach, umpolung

Abstract: Aryl C-glycosides are stable analogs of the corresponding O-glycosides. Because of their favorable pharmacological profiles attributed primarily to the C-glycosyl moiety, aryl C-glycosides have gained increasing popularity as drug candidates. In this review we focus on the synthesis of aryl C-glycosides including puerarin and kendomycin. This review is organized based on the type of chemistry used in the assembly of the C-glycosides with the following sub-sections: electrophilic reaction, cross-coupling reaction, free radical reaction, cyclization, intramolecular OC rearrangement, umpolung, and miscellaneous reactions.

Cite this article as:

Lee Y. W. David and He Minsheng, Recent Advances in Aryl C-Glycoside Synthesis, Current Topics in Medicinal Chemistry 2005; 5 (14) . https://dx.doi.org/10.2174/156802605774643042