Are Oblique Orientated α-Helices Used by Antimicrobial Peptides for Membrane Invasion?

Title: Are Oblique Orientated α-Helices Used by Antimicrobial Peptides for Membrane Invasion?

Volume: 12 Issue: 1

Author(s): Sarah R. Dennison, Frederick Harris and David A. Phoenix

Affiliation:

Keywords: peptides, hydrophobicity, membrane destabilisation, haemolysis, non-bilayer lipid structures

Abstract: Oblique orientated α-helices are highly specialised protein structural elements that penetrate membranes at a shallow angle and are used to promote membrane destabilisation by a number of protein classes. Here, the use of extended hydrophobic moment methodology shows that the amphibian extrudates, aurein 1.2 and citropin 1.1, may use oblique orientated α-helices in their antimicrobial action and that such use may be shared by other antimicrobial peptides. This appears to be the first systematic analysis of these peptides for the possession of oblique orientated a-helical structure.

Cite this article as:

Dennison R. Sarah, Harris Frederick and Phoenix A. David, Are Oblique Orientated α-Helices Used by Antimicrobial Peptides for Membrane Invasion?, Protein & Peptide Letters 2005; 12 (1) . https://dx.doi.org/10.2174/0929866053406039

DOI https://dx.doi.org/10.2174/0929866053406039	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305