Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

Title: Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

Volume: 12 Issue: 7

Author(s): L. M. Ritter, T. Arakawa and A. F.X. Goldberg

Affiliation:

Keywords: peripherin/rds, tetraspanin, intrinsically disordered, natively unstructured, photoreceptor, outer segment

Abstract: Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this proteins C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

Cite this article as:

Ritter M. L., Arakawa T. and Goldberg F.X. A., Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin, Protein & Peptide Letters 2005; 12 (7) . https://dx.doi.org/10.2174/0929866054696217

DOI https://dx.doi.org/10.2174/0929866054696217	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305