Key Aspects of the Novartis Compound Collection Enhancement Project for the Compilation of a Comprehensive Chemogenomics Drug Discovery Screening Collection

Pascal      Rigollier; Hans-   Joerg   Roth; Jurg      Zimmermann; Karine      Malagu; Jurgen      Hinrichs; Rudolph      Giger; David      Orain; Peter      Meier; Guido      Koch; Friederike      Stoll; Edgar      Jacoby; Pierre      Acklin; Jaroslav      Stanek; Caroline      Engeloch; Ulrich      Schopfer; Benjamin      Havill; Kamal      Azzaoui; Maxim      Popov; Ansgar      Schuffenhauer

doi:10.2174/1568026053828376

Abstract

The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehensive screening collection for a modern drug discovery organization. The main purpose of the screening collection is to supply the Novartis drug discovery pipeline with hit-to-lead compounds for todays and the futures portfolio of drug discovery programs, and to provide tool compounds for the chemogenomics investigation of novel biological pathways and circuits. As such, it integrates designed focused and diversity-based compound sets from the synthetic and natural paradigms able to cope with druggable and currently deemed undruggable targets and molecular interaction modes. Herein, we will summarize together with new trends published in the literature, scientific challenges faced and key approaches taken at NIBR to match the chemical and biological spaces.

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