Attempts Towards the Synthesis of Feigrisolide B

K.   Raman   Kumar; G.   V.M.   Sharma

doi:10.2174/157017807782006326

Abstract

Synthesis of lactones 3 and 4 is reported in an attempt towards the synthesis of natural product feigrisolide B. Sharpless asymmetric epoxidation and Gillman epoxide opening reactions were used for the construction of the required framework containing two stereocentres. The lactones 3 and 4 revealed that the proposed structure for feigrisolide B is incorrect.

Keywords: Feigrisolide B, sharpless asymmetric epoxidation, yamaguchi cyclisation, wittig reaction, gillman epoxide opening reaction, oxidation

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Letters in Organic Chemistry

Title: Attempts Towards the Synthesis of Feigrisolide B

Volume: 4 Issue: 7

Author(s): K. Raman Kumar and G. V.M. Sharma

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Keywords: Feigrisolide B, sharpless asymmetric epoxidation, yamaguchi cyclisation, wittig reaction, gillman epoxide opening reaction, oxidation

Abstract: Synthesis of lactones 3 and 4 is reported in an attempt towards the synthesis of natural product feigrisolide B. Sharpless asymmetric epoxidation and Gillman epoxide opening reactions were used for the construction of the required framework containing two stereocentres. The lactones 3 and 4 revealed that the proposed structure for feigrisolide B is incorrect.

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Kumar Raman K. and Sharma V.M. G., Attempts Towards the Synthesis of Feigrisolide B, Letters in Organic Chemistry 2007; 4 (7) . https://dx.doi.org/10.2174/157017807782006326