First In Vivo Evaluation of a New Morpholine Analog

Title: First In Vivo Evaluation of a New Morpholine Analog

Volume: 4 Issue: 7

Author(s): M. Altamura, A. Guidi, F. Pasqui, M. Tramontana and K. Worm-Leonhard

Affiliation:

Keywords: Tachykinins, Neurokinin A, 6,8-dioxa-3-aza-bicyclo(3.2.1)octane, Morpholine, Oligomer

Abstract: The scope of 6,8-dioxa-3-aza-bicyclo(3.2.1)octane derivatives as morpholine replacing groups in bioactive compounds was investigated. Four derivatives were synthesized and subjected to the routinary screening strategy, as part of a project directed to obtain new tachykinin NK2 antagonists. The obtained results encourage further study on the heterobicycle 6,8-dioxa-3-aza-bicyclo(3.2.1)octane as morpholine surrogate.

Cite this article as:

Altamura M., Guidi A., Pasqui F., Tramontana M. and Worm-Leonhard K., First In Vivo Evaluation of a New Morpholine Analog, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788534

DOI https://dx.doi.org/10.2174/157018007781788534	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X