Microwave and Polymer Assisted Synthesis of a Small Library of α ,β -Unsaturated Methyl Esters via the Wittig Reaction

S. Collina; D. Rossi; M. Urbano; A. Carnevale Baraglia; O. Azzolina

doi:10.2174/157017807781467650

Abstract

An efficient protocol based on the combination of microwave dielectric heating and PASP synthesis using the Wittig reaction was developed and applied to the preparation of α,β-unsaturated methyl esters, key intermediates of new sigma ligands. The stereochemistry of the products was also investigated showing a high E:Z isomeric ratio.

Keywords: Wittig reaction, MAOS, PASPS, sigma ligands intermediates, E:Z isomeric ratio

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Letters in Organic Chemistry

Title: Microwave and Polymer Assisted Synthesis of a Small Library of α ,β -Unsaturated Methyl Esters via the Wittig Reaction

Volume: 4 Issue: 6

Author(s): S. Collina, D. Rossi, M. Urbano, A. Carnevale Baraglia and O. Azzolina

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Keywords: Wittig reaction, MAOS, PASPS, sigma ligands intermediates, E:Z isomeric ratio

Abstract: An efficient protocol based on the combination of microwave dielectric heating and PASP synthesis using the Wittig reaction was developed and applied to the preparation of α,β-unsaturated methyl esters, key intermediates of new sigma ligands. The stereochemistry of the products was also investigated showing a high E:Z isomeric ratio.

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S. Collina , D. Rossi , M. Urbano , A. Carnevale Baraglia and O. Azzolina , Microwave and Polymer Assisted Synthesis of a Small Library of α ,β -Unsaturated Methyl Esters via the Wittig Reaction, Letters in Organic Chemistry 2007; 4 (6) . https://dx.doi.org/10.2174/157017807781467650