Bacteriorhodopsin Analogue from Indolic Chromophores

Prasanta Kumar Hota; Anil Kumar Singh

doi:10.2174/157017807781024228

Abstract

A new analogue of bacteriorhodopsin (bR) was prepared by allowing bacterioopsin (bOP), the apo-protein of bR to interact with (2Z,4E)-3-chloro-5-(1H-indol-3-yl)-2,4-pentadienal as chromophore. It was characterised for its opsin shift, stability, light-induced pH change and fluorescence emission. Indolic aldehydes viz. 1H-indole-3-carboxaldehyde and (2Z,4E)-3-chloro-5-[1-(phenylsulfonyl)-1H-indol-3-yl]-2,4-pentadienal did not bind bOP.

Keywords: Bacteriorhodopsin, Indole, Bacteriorhodopsin analogues, Opsin shift, Rhodopsins

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Letters in Organic Chemistry

Title: Bacteriorhodopsin Analogue from Indolic Chromophores

Volume: 4 Issue: 4

Author(s): Prasanta Kumar Hota and Anil Kumar Singh

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Keywords: Bacteriorhodopsin, Indole, Bacteriorhodopsin analogues, Opsin shift, Rhodopsins

Abstract: A new analogue of bacteriorhodopsin (bR) was prepared by allowing bacterioopsin (bOP), the apo-protein of bR to interact with (2Z,4E)-3-chloro-5-(1H-indol-3-yl)-2,4-pentadienal as chromophore. It was characterised for its opsin shift, stability, light-induced pH change and fluorescence emission. Indolic aldehydes viz. 1H-indole-3-carboxaldehyde and (2Z,4E)-3-chloro-5-[1-(phenylsulfonyl)-1H-indol-3-yl]-2,4-pentadienal did not bind bOP.

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Prasanta Kumar Hota and Anil Kumar Singh , Bacteriorhodopsin Analogue from Indolic Chromophores, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024228