Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

Title: Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids

Volume: 4 Issue: 5

Author(s): Abderrahmane Yahyi, Abdelkader Ettouhami, Smaail Radi, Ismail Zidane, Abdelkader Hakkou and Mohamed Bouakka

Affiliation:

Keywords: Pyrazolic acids, Triphenyltin derivatives, Biological activities

Abstract: The synthesis of new triphenyltin derivatives with (N-substituted-pyrazol-3-yl) carboxylic acid fragments is described. The in vitro antibacterial activity of the new agents was evaluated against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). A considerable activity was recorded with respect to the three studied micro-organisms. Structure activity relationship studies (SAR) reflect the effect of substituted pyrazolic fragment.

Cite this article as:

Yahyi Abderrahmane, Ettouhami Abdelkader, Radi Smaail, Zidane Ismail, Hakkou Abdelkader and Bouakka Mohamed, Synthesis and Biological Activities of New Triphenyl Organotin (IV) Based on the Pyrazole Carboxylic Acids, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867889

DOI https://dx.doi.org/10.2174/157018007780867889	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X