Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain

Title: Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain

Volume: 4 Issue: 5

Author(s): Dominique Gallo, Yves Jacquot, Anny Cleeren, Francoise Jacquemotte, Ioanna Laios, Guy Laurent and Guy Leclercq

Affiliation:

Keywords: Estrogen Receptor, Synthetic Peptide, ERα17p, Regulatory Motif, AF-2

Abstract: ERα17p is a synthetic peptide corresponding to a regulatory motif located within the autonomous AF-2a region of the estrogen receptor α (ERα). ERα17p binds to the receptor and enhances its transcriptional activity. Structural characteristics of this peptide suggest that it interferes with intra- and/or interprotein interactions involving ERα.

Cite this article as:

Gallo Dominique, Jacquot Yves, Cleeren Anny, Jacquemotte Francoise, Laios Ioanna, Laurent Guy and Leclercq Guy, Molecular Basis of Agonistic Activity of ERα17p, a Synthetic Peptide Corresponding to a Sequence Located at the N-Terminal Part of the Estrogen Receptor αLigand Binding Domain, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867807

DOI https://dx.doi.org/10.2174/157018007780867807	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X