Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines

Lal      Dhar Singh Yadav; Ritu      Kapoor

doi:10.2174/157017807780737228

Abstract

A nanoclay-catalyzed atom and energy-efficient low hazardous tandem conjugate additioncyclodehydration of cyclic thioureas (ethylenethiourea and 2-mercaptoimidazole/-benzimidazole) with dielectrophiles (chalcones) readily annulates a 1,3-thiazine ring on imidazoles to yield 7H-imidazo[2,1-b]-1,3- thiazines under solvent-free microwave irradiation in a one-pot procedure.

Keywords: Nanoclay-catalyzed, solvent-free, chalcones, cyclic thioureas, microwaves, imidazo-1,3-thiazines

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Letters in Organic Chemistry

Title: Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines

Volume: 4 Issue: 3

Author(s): Lal Dhar Singh Yadav and Ritu Kapoor

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Keywords: Nanoclay-catalyzed, solvent-free, chalcones, cyclic thioureas, microwaves, imidazo-1,3-thiazines

Abstract: A nanoclay-catalyzed atom and energy-efficient low hazardous tandem conjugate additioncyclodehydration of cyclic thioureas (ethylenethiourea and 2-mercaptoimidazole/-benzimidazole) with dielectrophiles (chalcones) readily annulates a 1,3-thiazine ring on imidazoles to yield 7H-imidazo[2,1-b]-1,3- thiazines under solvent-free microwave irradiation in a one-pot procedure.

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Dhar Singh Yadav Lal and Kapoor Ritu, Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737228