Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

Title: Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

Volume: 4 Issue: 4

Author(s): K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia and B. B. Aggarwal

Affiliation:

Keywords: Human myeloid leukemia, Copper complexes, Naphthoquinones, Sulforaphanes, NF-κB inhibition, Henna derivatives

Abstract: The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC50 of 0.3 μM attributed to down regulation of NF-κB activation.

Cite this article as:

Shirisha K., Patole J., Padhye S., Sinn E., Shishodia S. and Aggarwal B. B., Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620059

DOI https://dx.doi.org/10.2174/157018007784620059	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X