Abstract
Quinazolinone alkaloids are a class of natural products possessing a variety of biological activities. In addition, the quinazolinone core scaffold has been extensively utilized as a drug-like template in medicinal chemistry and considered a privileged structure. We have devised a novel, one-pot, highly efficient entry into multiply substituted quinazolinones using microwave technology and applied this methodology to the total syntheses of series of quinazolinone-containing natural products. This review will highlight the total syntheses of these natural products and their analogs under microwave conditions.
Keywords: Natural Products, Microwave Irradiation, Alantrypinone, quinazolinobenzodiazepine alkaloid, asperlicin E, isaindigotone
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