Synthesis of the C-13 Side-Chain of Taxol

Jagat   C.   Borah; Joshodeep      Boruwa; Nabin   C.   Barua

doi:10.2174/157017907780598899

Abstract

This review covers different synthetic routes to the C-13 side-chain of taxol the most potent antimicrotubule agent first isolated from Texus bravifolia and later on from several other species of Taxus. The different approaches reported for the syntheses of the C-13 side-chain of taxol are catagorized on the synthetic strategies applied.

Keywords: Taxol, 10-DAB, C-13 side-chain, total synthesis, antimicotubule

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Current Organic Synthesis

Title: Synthesis of the C-13 Side-Chain of Taxol

Volume: 4 Issue: 2

Author(s): Jagat C. Borah, Joshodeep Boruwa and Nabin C. Barua

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Keywords: Taxol, 10-DAB, C-13 side-chain, total synthesis, antimicotubule

Abstract: This review covers different synthetic routes to the C-13 side-chain of taxol the most potent antimicrotubule agent first isolated from Texus bravifolia and later on from several other species of Taxus. The different approaches reported for the syntheses of the C-13 side-chain of taxol are catagorized on the synthetic strategies applied.

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Borah C. Jagat, Boruwa Joshodeep and Barua C. Nabin, Synthesis of the C-13 Side-Chain of Taxol, Current Organic Synthesis 2007; 4 (2) . https://dx.doi.org/10.2174/157017907780598899