New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling

Marco      Franceschin; Stefano      Frasca; Antonello      Alvino; Armandodoriano      Bianco

doi:10.2174/157017807780414217

Abstract

A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.

Keywords: Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines

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Letters in Organic Chemistry

Title: New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling

Volume: 4 Issue: 2

Author(s): Marco Franceschin, Stefano Frasca, Antonello Alvino and Armandodoriano Bianco

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Keywords: Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines

Abstract: A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.

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Franceschin Marco, Frasca Stefano, Alvino Antonello and Bianco Armandodoriano, New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414217