Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides

Zhiming      Wang; Zhe      Li; Weiliang      Bao

doi:10.2174/157017807780037333

Abstract

A real continuous-flow process for synthesis of alkyl bromides or cyanides was demonstrated by nucleophilic substitution reactions of tosylates with bromide and/or cyanide conducted in ionic liquid 1- ethyl-3-methylimidazolium tosylate. The process provides higher yields and shorter reaction time and is easily upgraded to large scale.

Keywords: Continuous-flow process, ionic liquid, nucleophilic substitution reaction, distillation, alkyl bromide, alkyl cyanide

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Letters in Organic Chemistry

Title: Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides

Volume: 4 Issue: 1

Author(s): Zhiming Wang, Zhe Li and Weiliang Bao

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Keywords: Continuous-flow process, ionic liquid, nucleophilic substitution reaction, distillation, alkyl bromide, alkyl cyanide

Abstract: A real continuous-flow process for synthesis of alkyl bromides or cyanides was demonstrated by nucleophilic substitution reactions of tosylates with bromide and/or cyanide conducted in ionic liquid 1- ethyl-3-methylimidazolium tosylate. The process provides higher yields and shorter reaction time and is easily upgraded to large scale.

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Wang Zhiming, Li Zhe and Bao Weiliang, Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037333