Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Title: Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Volume: 3 Issue: 12

Author(s): Jose C. Barros, Joaquim F. M. da Silva, Alexandre R. Calazans, Amilcar Tanuri, Rodrigo de Morais Brindeiro, John S. Williamson and Octavio A.C. Antunes

Affiliation:

Keywords: AIDS, HIV, tartaric acid, C2 symmetry, protease inhibitors, pseudopeptides

Abstract: New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.

Cite this article as:

Barros C. Jose, M. da Silva F. Joaquim, Calazans R. Alexandre, Tanuri Amilcar, Brindeiro Rodrigo de Morais, Williamson S. John and Antunes A.C. Octavio, Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468040