Convenient Synthesis of α-Amino Acid-Derived Cyclic Amides for Use as Building Blocks for Protease Inhibitors

Title: Convenient Synthesis of α-Amino Acid-Derived Cyclic Amides for Use as Building Blocks for Protease Inhibitors

Volume: 3 Issue: 11

Author(s): Maxim E. Sergeev and Tatiana L. Voyushina

Affiliation:

Keywords: Amino acids, amides, enzymes, inhibitors, affinity chromatography

Abstract: An efficient and straightforward approach towards the synthesis of a-amino acid-derived cyclic amides was developed. A series of cyclic amides of various natural amino acids were obtained in excellent yields under mild conditions. The obtained compounds could be efficiently used as ligands for affinity chromatography of enzymes.

Cite this article as:

Sergeev E. Maxim and Voyushina L. Tatiana, Convenient Synthesis of α-Amino Acid-Derived Cyclic Amides for Use as Building Blocks for Protease Inhibitors, Letters in Organic Chemistry 2006; 3 (11) . https://dx.doi.org/10.2174/157017806779117102