Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

Title: Target Structure-based Modeling of the Glutamate Transporter Pharmacophore

Volume: 3 Issue: 5

Author(s): A. Simon, A. Bencsura and J. Kardos

Affiliation:

Keywords: Glutamate transporter, metabotropic Glu receptor subtype 1, docking and molecular dynamics, glutamate, L-trans-2, 4-PDC, GABA

Abstract: Comparison of binding interactions of a bacterial Glu transporter homologue and the extracellular binding domain of metabotropic Glu receptor subtype (mGlu1) showed Glu adopting bent and extended conformations in Glu transporter and mGlu1, respectively.

Cite this article as:

Simon A., Bencsura A. and Kardos J., Target Structure-based Modeling of the Glutamate Transporter Pharmacophore, Letters in Drug Design & Discovery 2006; 3 (5) . https://dx.doi.org/10.2174/157018006777574230

DOI https://dx.doi.org/10.2174/157018006777574230	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X