Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration

Title: Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration

Volume: 6 Issue: 11

Author(s): Maria L. Bolognesi, Anna Minarini, Vincenzo Tumiatti and Carlo Melchiorre

Affiliation:

Keywords: Neurodegenerative diseases, Lipoic acid, Antioxidants, Multi-target-directed drugs, Reactive oxygen species

Abstract: Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.

Cite this article as:

Bolognesi L. Maria, Minarini Anna, Tumiatti Vincenzo and Melchiorre Carlo, Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742731