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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Oleoylethanolamide: a Molecular Cross-Talk with Leptin in Feeding Behaviour Regulation

Author(s): Buenaventura Brito, Rafael Castro and Antonio Cabrera de Leon

Volume 3, Issue 10, 2006

Page: [741 - 746] Pages: 6

DOI: 10.2174/157018006778631901

Price: $65

Abstract

Oleoylethanolamide is an endogenous lipid mediator that reduces food intake and decreases body weight gain in rodents. As in leptin, oleoylethanolamide has a central and peripheral anorexic effect. In this article, we describe common potential targets, suggesting a molecular cross-talk between leptin and oleoylethanolamide which may regulate feeding behaviour.

Keywords: Oleoylethanolamide (OEA), Leptin, Obesity, Anorexigenic, Feeding behaviour, Anti-obesity effects, Rats


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