A Novel and Convenient Method for the Synthesis of Ubiquinone-10

Feng      Wang; Xiangrui      Jiang; Lihong      Hu; Shengyi      Dong; Xiumei      Wu; Hua      Bai; Yongmin      Zhang; Joachim      Stockigt; Yu      Zhao

doi:10.2174/157017806778559464

Abstract

A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2-type nucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylic acetate, which was suitable for the large-scale production of ubiquinone-10.

Keywords: SN2'-type reaction, copper-catalyzed, Grignard reagent, secondary allylic acetate, regioselectivity, stereoselectivity

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Letters in Organic Chemistry

Title: A Novel and Convenient Method for the Synthesis of Ubiquinone-10

Volume: 3 Issue: 8

Author(s): Feng Wang, Xiangrui Jiang, Lihong Hu, Shengyi Dong, Xiumei Wu, Hua Bai, Yongmin Zhang, Joachim Stockigt and Yu Zhao

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Keywords: SN2'-type reaction, copper-catalyzed, Grignard reagent, secondary allylic acetate, regioselectivity, stereoselectivity

Abstract: A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2-type nucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylic acetate, which was suitable for the large-scale production of ubiquinone-10.

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Wang Feng, Jiang Xiangrui, Hu Lihong, Dong Shengyi, Wu Xiumei, Bai Hua, Zhang Yongmin, Stockigt Joachim and Zhao Yu, A Novel and Convenient Method for the Synthesis of Ubiquinone-10, Letters in Organic Chemistry 2006; 3 (8) . https://dx.doi.org/10.2174/157017806778559464