Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors

Anastassios      Vourekas; Dimitra      Kalavrizioti; Constantinos      Stathopoulos; Denis      Drainas

doi:10.2174/138955706778195199

Abstract

Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are capable of serving as a new molecular target for a variety of drugs and as a reliable screening system for their biological activity.

Keywords: Ribozymes, RNase P, ribosome, drug target, aminoglycosides, macrolides, retinoids, calcipotriol

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Mini-Reviews in Medicinal Chemistry

Title: Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors

Volume: 6 Issue: 9

Author(s): Anastassios Vourekas, Dimitra Kalavrizioti, Constantinos Stathopoulos and Denis Drainas

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Keywords: Ribozymes, RNase P, ribosome, drug target, aminoglycosides, macrolides, retinoids, calcipotriol

Abstract: Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are capable of serving as a new molecular target for a variety of drugs and as a reliable screening system for their biological activity.

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Vourekas Anastassios, Kalavrizioti Dimitra, Stathopoulos Constantinos and Drainas Denis, Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195199