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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Access to Chiral N-Substituted 1,4-Dihydropyridines Through the One-Pot Domino Michael-Azacyclization Process

Author(s): N. Monnier-Benoit, I. Jabin and P. Netchitailo

Volume 3, Issue 7, 2006

Page: [549 - 553] Pages: 5

DOI: 10.2174/157017806778341834

Price: $65

Abstract

The one-pot domino Michael-azacyclization process was applied to the synthesis of chiral Nsubstituted 1,4-dihydropyridines. Chiral enaminoesters were reacted with alkylidene malonate olefins or α,β- ethylenic aldehydes. The crucial role of the α-substituent of the starting enaminoester both on the diastereoselectivity and on the orientation of the reaction was clearly evidenced.

Keywords: 1,4-dihydropyridines, aza-Michael, enaminoesters


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