Practical Method for Parallel Synthesis of Diversely Substituted 1- henylpiperazines

Igor      Konstantinov; Konstantin      Bukhryakov; Yuri      Gezentsvey; Mikhail      Krasavin

doi:10.2174/157017811799304386

Abstract

A simple and practical method to prepare ‘libraries’ of substituted 1-phenylpiperazine building blocks in parallel format has been developed.

Keywords: Bis-alkylation, N-arylpiperazines, nitrogen mustard, parallel synthesis, solvent-free synthesis, SAR-informative, 1-phenylpiperazines, morpholine, iminodiethanol, ethanamine

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Letters in Organic Chemistry

Title: Practical Method for Parallel Synthesis of Diversely Substituted 1- henylpiperazines

Volume: 8 Issue: 9

Author(s): Igor Konstantinov, Konstantin Bukhryakov, Yuri Gezentsvey and Mikhail Krasavin

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Keywords: Bis-alkylation, N-arylpiperazines, nitrogen mustard, parallel synthesis, solvent-free synthesis, SAR-informative, 1-phenylpiperazines, morpholine, iminodiethanol, ethanamine

Abstract: A simple and practical method to prepare ‘libraries’ of substituted 1-phenylpiperazine building blocks in parallel format has been developed.

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Konstantinov Igor, Bukhryakov Konstantin, Gezentsvey Yuri and Krasavin Mikhail, Practical Method for Parallel Synthesis of Diversely Substituted 1- henylpiperazines, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304386