The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Title: The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Volume: 13 Issue: 6

Author(s): Frederick Harris, Sarah Dennison and David A Phoenix

Affiliation:

Keywords: Oblique orientated α-helix, hydrophobicity gradient, hydropathy plot analysis, hydrophobic moment, amphiphilic profiling, transmembrane protein

Abstract: Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.

Cite this article as:

Harris Frederick, Dennison Sarah and Phoenix A David, The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique, Protein & Peptide Letters 2006; 13 (6) . https://dx.doi.org/10.2174/092986606777145832

DOI https://dx.doi.org/10.2174/092986606777145832	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305