Investigation of Superparamagnetic Iron Oxide Nanoparticles for MRVisualization of Surgical Implants

I.      Slabu; G.      Guntherodt; T.      Schmitz-Rode; M.      Hodenius; N.      Kramer; H.      Donker; G.      A. Krombach; J.      Otto; U.      Klinge; M.      Baumann

doi:10.2174/138920112799436249

Abstract

For the development of a surgical mesh implant that is visible in magnetic resonance imaging (MRI), superparamagnetic iron oxides (SPIOs) are integrated into the material of the mesh. In order to get a high quality mesh regarding both mechanical and imaging properties, a narrow size distribution and homogenous spatial distribution, as well as a strong magnetization of SPIOs within the filament of the mesh are required. In this work, six different samples of SPIOs composed of a magnetite core are synthesized with and without stabilizing dodecanoic acid and analyzed using a superconducting quantum interference device (SQUID), transmission electron microscope (TEM) and a magnetic force microscope (MFM) to determine the properties that are beneficial for the assembly and imaging of the implant. These analyses show the feasibility of visualization of surgical implants with incorporated SPIOs and the influence of the agglomeration of SPIOs on their magnetization and on a homogenous spatial distribution within the polymer of the mesh.

Keywords: Magnetic force microscopy, magnetic resonance imaging, nanomaterials, superconducting quantum interference device, superparamagnetic iron oxides, surgical implants, surgical mesh implant, homogenous, SPIOs, transmission electron microscope (TEM), medical diagnostics, signal voids, homogeneous distribution, chloride hexahydrate