Metabolomics: A Revolution for Novel Cancer Marker Identification

Qian      Bu; Yina      Huang; Guangyan      Yan; Xiaobo      Cen; Ying-Lan      Zhao

doi:10.2174/138620712799218563

Abstract

The repertoire of small-molecular-weight substances present in cells, tissue and body fluids are known as the metabolites. The global analysis of metabolites, such as by high-resolution 1H nuclear magnetic resonance spectroscopy and mass spectrometry, is integral to the rapidly expanding field of metabolomics, which is making progress in various diseases. In the area of cancer and metabolic phenotype, the integrated analysis of metabolites may provide a powerful platform for detecting changes related to cancer diagnosis and discovering novel biomarkers. In this review, metabolomics including the technologies in metabolomics research and extracting information from metabolomics datasets are described. Then we discuss the challenges and opportunities in metabolomics for finding metabolic processes in cancer and discovering novel cancer biomarkers. Finally, we assess the clinical applicability of metabolomics.

Keywords: Biomarker identification, cancer, metabolomics, body fluids, high-resolution, mass spectrometry, biomarkers, biochemical processes, DNA, RNA, protein, concentrations, interactions, gene expression, endogenous, metabolities, NMR spectroscopy, biofluids, pattern recognition (PR)