Novel Anti-Viral Therapy: Drugs that Block HIV Entry at Different Target Sites

Sandra      Siegert; Peter      Schnierle; Barbara   S.   Schnierle

doi:10.2174/138955706776876267

Abstract

Drugs that block the entry of human immunodeficiency virus type 1 (HIV-1) into host cells abrogate the establishment of a productive infection and should ideally diminish the chances of HIV-1 developing resistance. This review will give an overview of the mechanism by which the envelope glycoprotein mediates HIV-1 entry and will summarize current drug developments.

Keywords: HIV, entry, inhibitor

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Mini-Reviews in Medicinal Chemistry

Title: Novel Anti-Viral Therapy: Drugs that Block HIV Entry at Different Target Sites

Volume: 6 Issue: 5

Author(s): Sandra Siegert, Peter Schnierle and Barbara S. Schnierle

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Keywords: HIV, entry, inhibitor

Abstract: Drugs that block the entry of human immunodeficiency virus type 1 (HIV-1) into host cells abrogate the establishment of a productive infection and should ideally diminish the chances of HIV-1 developing resistance. This review will give an overview of the mechanism by which the envelope glycoprotein mediates HIV-1 entry and will summarize current drug developments.

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Siegert Sandra, Schnierle Peter and Schnierle S. Barbara, Novel Anti-Viral Therapy: Drugs that Block HIV Entry at Different Target Sites, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876267