Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies

Title: Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies

Volume: 6 Issue: 5

Author(s): Dominik Wolf, Holger Rumpold and Anna-Maria Wolf

Affiliation:

Keywords: Biochemical modification, regulatory T cell, immune evasion, cancer

Abstract: CD4+CD25+ T cells are essential for maintenance of self-tolerance and therefore have been referred to as regulatory T cells (Treg). Experimental tumor models revealed that Treg are potent inhibitors of an anti-tumor immune response. Treg are expanded in human cancer. Currently, a variety of strategies for the induction of a specific anti-tumor immune response are tested in preclinical and clinical settings. Biochemical strategies modifying and/or depleting Treg in cancer patients for an enhancement of vaccine-based therapeutic concepts will be discussed in detail in this review.

Cite this article as:

Wolf Dominik, Rumpold Holger and Wolf Anna-Maria, Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876230