Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity

C.   E.   Oyiliagu; M.      Novalen; L.   P.   Kotra

doi:10.2174/157019306776819235

Abstract

Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.

Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors

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Mini-Reviews in Organic Chemistry

Title: Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity

Volume: 3 Issue: 2

Author(s): C. E. Oyiliagu, M. Novalen and L. P. Kotra

Affiliation:

Keywords: Fluoropeptidomimetics, fluorine substitution, peptidomimicry, protease inhibitors

Abstract: Fluorine atom has been used extensively to modulate the properties of various peptide-like compounds to modulate enzyme activities such as proteases. Fluorinated functionalities such as trifluoromethyl group, difluoromethyl group, fluoromethyl moiety and recently -CHF-S- were investigated. This article discusses important fluorine containing peptidomimetics, synthetic strategies, and the modulation of enzymic activities.

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Oyiliagu E. C., Novalen M. and Kotra P. L., Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity, Mini-Reviews in Organic Chemistry 2006; 3 (2) . https://dx.doi.org/10.2174/157019306776819235