Abstract
The Meyers reaction, i.e. the nucleophilic aromatic substitution reaction between aryloxazolines with organolithium and organomagnesium reagents is a very efficient and reliable method for the formation of new carbon-carbon and carbon-heteroatom bonds. The aim of this review is to present a general overview of this reaction in chiral and racemic form, emphasizing its scope and limitations. The literature is covered since 1994.
Keywords: Nucleophilic aromatic substitution, Meyers reaction, oxazolines, Grignard reagents, organolithium reagents, nucleophilic aromatic substitution reaction, aryloxazolines, organolithium, organomagnesium reagents, carbon-heteroatom bonds, racemic form, indolines, indans, tetralins, benzofurans
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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