4-Vinylpyridine-Based Smart Nanoparticles with N-Isopropylacrylamide, 2-Hydroxyethyl Methacrylate, Acrylic acid, and Methacrylic Acid for Potential Biomedical Applications

Nurettin      Sahiner; Ozgur      Ozay; Nahit      Aktas

doi:10.2174/157341311795542507

Abstract

Stimuli-responsive (pH, temperature and magnetic field) 4-vinylpyridine (4-VP)-based nanoparticles in copolymeric formulation with core-shell morphology were synthesized using N-isopropylacrylamide (NIPAM), 2-hydroxyethyl methacrylate (HEMA), acrylic acid (AAc), and methacrylic acid (MAc) as shell-forming monomers. Keeping the 4-VP ratio constant and varying the comonomer amounts produced particles with variant shell thickness. Multi-responsive p(4-VP)-based nanoparticles were further modified by reacting with different functional groups containing bromoalkanes by quaternization. These p(4-VP)-based particles were also utilized to include composite materials by encapsulating separately prepared magnetic ferrites. To demonstrate the potential usage of the synthesized particles and their modified forms as drug delivery devices, naproxene sodium salt as an antibacterial drug was used for in vitro release studies in PBS.

Keywords: Smart-nanogel, multi-responsive particle, core-shell particles, drug delivery, microgel, Smart-microgels, intelligent-nanogels, stimuli responsive particles, verstaile polymeric particles, magnetic field sensitive particles, thermoresponsive particles, nano composites, targeted delivery, one step synthesis of cores-shell particles, biomedical applications, 4-vinylpyridine, N-isopropylacrylamide, acrylic acid, methacrylic acid