Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice

Title: Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice

Volume: 9 Issue: 1

Author(s): E.-J. Shin, J.-M. Kim, X.-K. T. Nguyen, T.-T. L. Nguyen, S. Y. Lee, J.-H. Jung, M. J. Kim, W. K. Whang, K. Yamada, T. Nabeshima and H.-C. Kim

Affiliation:

Keywords: Gastrodia elata Bl, phencyclidine, schizophrenia, 5-HT1A receptors, chronic, devastating, anxiolytic, anti-depressant, anti-convulsant, anti-oxidant, anti-depressant effects

Abstract: It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

Cite this article as:

Shin E.-J., Kim J.-M., T. Nguyen X.-K., L. Nguyen T.-T., Y. Lee S., Jung J.-H., J. Kim M., K. Whang W., Yamada K., Nabeshima T. and Kim H.-C., Effects of Gastrodia Elata Bl on Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice, Current Neuropharmacology 2011; 9 (1) . https://dx.doi.org/10.2174/157015911795017263