HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Title: HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2

Volume: 3 Issue: 3

Author(s): Yasutomo Nomura, Hiroyuki Fujiwara, Kohei Ito, Hirobumi Fuchigami, Michihiko Sato, Eiji Takahashi, Yasukazu Hozumi, Kaoru Goto, Zhonggang Feng and Takao Nakamura

Affiliation:

Keywords: HIF-1α, cobalt, H2O2, cell growth, mitochondria, DNA damage

Abstract: Severity of ischemia/reperfusion injury accompanied with generation of reactive oxygen species is reduced by hypoxic preconditioning, the precise mechanisms of which are not completely understood. We found that cobalt-induced hypoxia-inducible factor-1α activity ameliorated suppression of cell growth caused by H2O2 through protecting mitochondrial DNA from oxidative damage.

Cite this article as:

Nomura Yasutomo, Fujiwara Hiroyuki, Ito Kohei, Fuchigami Hirobumi, Sato Michihiko, Takahashi Eiji, Hozumi Yasukazu, Goto Kaoru, Feng Zhonggang and Nakamura Takao, HIF-1α as a Target for Drug Design in Ischemic Injury: Effect of Cobalt Treatment on Mitochondrial DNA Damage in Cells Exposed to H2O2, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286952

DOI https://dx.doi.org/10.2174/157018006776286952	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X