Antiviral Sensing in Teleost Fish

Title: Antiviral Sensing in Teleost Fish

Volume: 16 Issue: 38

Author(s): Jun Zou, Steve Bird and Chris Secombes

Affiliation:

Keywords: Pattern recognition, Toll like receptors, RIG-I like receptor, protein kinase R, teleost fish

Abstract: Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.

Cite this article as:

Zou Jun, Bird Steve and Secombes Chris, Antiviral Sensing in Teleost Fish, Current Pharmaceutical Design 2010; 16 (38) . https://dx.doi.org/10.2174/138161210794519093