Aerosol Delivery of Antimicrobial Agents During Mechanical Ventilation: Current Practice and Perspectives

Title: Aerosol Delivery of Antimicrobial Agents During Mechanical Ventilation: Current Practice and Perspectives

Volume: 8 Issue: 2

Author(s): Argyris Michalopoulos, Eugenios I. Metaxas and Matthew E. Falagas

Affiliation:

Keywords: Antibiotics, delivery system, inhalation, nebulization, ventilation

Abstract: Critically ill patients, who develop ventilator-associated pneumonia during prolonged mechanical ventilation, often require antimicrobial agents administered through the endotracheal or the tracheotomy tube. The delivery of antibiotics via the respiratory tract has been established over the past years as an alternative route in order to deliver high concentrations of antimicrobial agents directly to the lungs and avoid systemic toxicity. Since the only formal indications for inhaled/aerosolized antimicrobial agents is for patients suffering from cystic fibrosis, consequently the majority of research and published studies concerns this group of patients. Newer devices and new antibiotic formulations are currently off-label used in ambulatory cystic fibrosis patients whereas similar data for the mechanically ventilated patients do not yet exist.

Cite this article as:

Michalopoulos Argyris, I. Metaxas Eugenios and E. Falagas Matthew, Aerosol Delivery of Antimicrobial Agents During Mechanical Ventilation: Current Practice and Perspectives, Current Drug Delivery 2011; 8 (2) . https://dx.doi.org/10.2174/156720111794479880