Self-Assembly-Based Structural DNA Nanotechnology

Zhao      Zhang; Yanming      Fu; Baojie      Li; Guoyin      Feng; Can      Li; Chunhai      Fan; Lin      He

doi:10.2174/138527211794474429

Abstract

Apart from providing the material for genetic information storage, DNA has also been regarded as a useful building block in the field of nanotechnology, which is known as DNA nanotechnology. Based on the Watson-Crick base-pairing and the famous double helical structure, a library of DNA 2D or 3D nanostructures has been designed, constructed and characterized, by either tile-based or origami- based self-assembly. More significantly, other molecules/nanomaterials can be organized on those DNA ensembles to achieve highly ordered arrays or specific patterns in nanometer spatial resolution. In this review, we summarize recent progress in creating DNA nanoarchitectures, and discuss potential applications in DNA-based nanofabrication.

Keywords: Structural DNA nanotechnology, DNA self-assembly, DNA nanoarchitectures, DNA origami, nanofabrication, Tile-Based DNA Self-Assembly, DX Tile (Double Crossover), hydroxyl radical cleavage pattern, nanogold, –, streptavidin conjugates, TX, PX paranemic crossover, PATX, 44 Tile (Cross Tile), mo-lecular lithography, Polygonal Tiles, Nanotubes, BTX, Polyhedron, XOR function, barcode-patterned lattice, cryo-electron microscopy, STM manipulation, monolith, square nut, railed bridge, genie bottle, stacked, slotted cross, biotin-streptavidin interaction, aptamer-protein binding, antigen-antibody reaction, direct chemical modification, DX array, linear TX, surface-patterning technique, SELEX, thrombin protein arrays, single-chain antibody, hybridization chain reaction, myc-epitope, anti-myc 9E10, Au Nanoparticle (AuNP)