Aquaporins and Neurodegenerative Diseases

Title: Aquaporins and Neurodegenerative Diseases

Volume: 8 Issue: 2

Author(s): Eleonora Foglio and Rodella Luigi Fabrizio

Affiliation:

Keywords: Aquaporins, CNS, Neurodegenerative Diseases

Abstract: Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis. Beside their physiological expression patterns in Central Nervous System (CNS), it is conceivable that AQPs are also abnormally expressed in some pathological conditions interesting CNS (e.g. neurodegenerative diseases) in which preservation of brain homeostasis is at risk. The purpose of this review was to take in consideration those neurodegenerative diseases in whose pathogenetic processes it was possible to hypothesize some alterations in CNS AQPs expression or modulation leading to damages of brain water homeostasis.

Cite this article as:

Foglio Eleonora and Luigi Fabrizio Rodella, Aquaporins and Neurodegenerative Diseases, Current Neuropharmacology 2010; 8 (2) . https://dx.doi.org/10.2174/157015910791233150