Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

Title: Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

Volume: 3 Issue: 1

Author(s): D. Sellanes, L. Scarone, G. Mahler, E. Manta, A. Baz, S. Dematteis, J. Saldana, L. Dominguez, P. Wipf and G. Serra

Affiliation:

Keywords: Bis-1,3-azoles, anthelmintic, cytotoxic, Bengazoles

Abstract: Tandem cyclizations to [2,5] bis-1,3-azoles provided simplified and stable models of biological active marine natural products. The cytotoxic activity in HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis of the heterocycles were evaluated and provided data that serve for the preparation of bioselective new therapeutic agents.

Cite this article as:

Sellanes D., Scarone L., Mahler G., Manta E., Baz A., Dematteis S., Saldana J., Dominguez L., Wipf P. and Serra G., Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products, Letters in Drug Design & Discovery 2006; 3 (1) . https://dx.doi.org/10.2174/157018006775240962

DOI https://dx.doi.org/10.2174/157018006775240962	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X