Solid-Phase Synthesis of Biologically Interesting Compounds Containing Hydroxamic Acid Moiety

Title: Solid-Phase Synthesis of Biologically Interesting Compounds Containing Hydroxamic Acid Moiety

Volume: 6 Issue: 1

Author(s): Viktor Krchnak

Affiliation:

Keywords: Hydroxamic acid, hydroxamate, solid-phase synthesis

Abstract: Chemical strategies developed for the solid-phase synthesis of hydroxamates are divided into four groups: (i) the traditional synthesis of hydroxamates via cleavage of resin-bound esters by hydroxylamine and its derivatives, (ii) introduction of hydroxamic acid moiety on the resin-bound precursor, (iii) transformation of polymer-supported hydroxylamine, attached to a solid supported linker either by oxygen (O-linking strategy) or by nitrogen (N-linking strategy), and (iv) synthesis of N-alkyl hydroxamates. The scope and limitation of individual approaches are discussed.

Cite this article as:

Krchnak Viktor, Solid-Phase Synthesis of Biologically Interesting Compounds Containing Hydroxamic Acid Moiety, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197811