Brevibacillus Expression System: Host-Vector System for Efficient Production of Secretory Proteins

Title: Brevibacillus Expression System: Host-Vector System for Efficient Production of Secretory Proteins

Volume: 11 Issue: 3

Author(s): Makoto Mizukami, Hiroshi Hanagata and Akira Miyauchi

Affiliation:

Keywords: Brevibacillus choshinensis, host-vector system, secretory production, recombinant protein, gram-positive bacteria

Abstract: Brevibacillus expression system is an effective bacterial expression system for secretory proteins. The host bacterium, Brevibacillus choshinensis, a gram-positive bacterium, has strong capacity to secrete a large amount of proteins (∼30g/L), which mostly consist of cell wall protein. A host-vector system that utilizes such high expression capacity has been constructed for the production of secretory proteins and tested for various heterologous proteins, including cytokines, enzymes, antigens, and adjuvants.

Cite this article as:

Mizukami Makoto, Hanagata Hiroshi and Miyauchi Akira, Brevibacillus Expression System: Host-Vector System for Efficient Production of Secretory Proteins, Current Pharmaceutical Biotechnology 2010; 11 (3) . https://dx.doi.org/10.2174/138920110791112031