Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

Title: Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies

Volume: 7 Issue: 4

Author(s): Saiju Jacob and Yusuf A. Rajabally

Affiliation:

Keywords: Intravenous immunoglobulins, mechanisms of action, inflammatory neuropathy, Guillain Barre syndrome, Chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy

Abstract: Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barre Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.

Cite this article as:

Jacob Saiju and Rajabally A. Yusuf, Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies, Current Neuropharmacology 2009; 7 (4) . https://dx.doi.org/10.2174/157015909790031166