The Role of Cytokines in Pharmacological Modulation of Hepatic Ischemia/Reperfusion Injury

Title: The Role of Cytokines in Pharmacological Modulation of Hepatic Ischemia/Reperfusion Injury

Volume: 12 Issue: 23

Author(s): Thomas L. Husted and Alex B. Lentsch

Affiliation:

Keywords: Ischemia/reperfusion, inflammation, cytokines, chemokines, adhesion molecules, NF-κB, neutrophils

Abstract: Hepatic ischemia/reperfusion injury is a complication of liver resection surgery, transplantation and hypovolemic shock, leading to local and remote cellular damage and organ dysfunction. This injury is largely a result of an acute inflammatory response characterized by the induction of a cascade of proinflammatory mediators that culminates in the recruitment of leukocytes to the post-ischemic tissue leading to parenchymal cell injury. Endogenous regulatory mechanisms exist to attempt to control this inflammatory response. These include anti-inflammatory cytokines that function to suppress proinflammatory mediator expression. In this review, we address the current knowledge of the pro- and anti-inflammatory cytokine components of the acute liver inflammatory response to ischemia/reperfusion as well as how these cytokines can be manipulated to reduce post-ischemic liver injury.

Cite this article as:

Husted L. Thomas and Lentsch B. Alex, The Role of Cytokines in Pharmacological Modulation of Hepatic Ischemia/Reperfusion Injury, Current Pharmaceutical Design 2006; 12 (23) . https://dx.doi.org/10.2174/138161206777947597