Abstract
This review summarizes the recent developments in transition metal-catalyzed 1,n-enyne cyclization reactions that have been reported in the literature from January 1, 2002 to April 30, 2005. The cyclizations described herein include four parts according the reaction mechanism, i. e. cyclization initiated by oxidative cyclometallation; by activation of the triple bond to form a vinyl metal species; by electrophilic activation of the triple bond; and by activation of the double bond. Enyne cyclizations that do not follow the above reaction mechanism are not included.
Keywords: E-double bond, electrophilic activation, five-membered ring products, cycloisomerization, phosphine l igands
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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