To be Excluded or to Bind, that is the Question: Arginine Effects on Proteins

Makoto      Nakakido; Motonori      Kudou; Tsutomu      Arakawa; Kouhei      Tsumoto

doi:10.2174/138920109788488824

Abstract

In spite of its wide application to protein refolding, purification, and storage, we have not yet addressed a general solution to the mechanism of the effects of arginine hydrochloride on proteins. To elucidate the mechanism of the effects on proteins, several attempts have been reported. In this review, we would review the attempts from thermodynamic and kinetic viewpoints.

Keywords: ArgHCl, guanidine, protein aggregation, preferential interaction, solubility, surface tension

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Current Pharmaceutical Biotechnology

Title: To be Excluded or to Bind, that is the Question: Arginine Effects on Proteins

Volume: 10 Issue: 4

Author(s): Makoto Nakakido, Motonori Kudou, Tsutomu Arakawa and Kouhei Tsumoto

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Keywords: ArgHCl, guanidine, protein aggregation, preferential interaction, solubility, surface tension

Abstract: In spite of its wide application to protein refolding, purification, and storage, we have not yet addressed a general solution to the mechanism of the effects of arginine hydrochloride on proteins. To elucidate the mechanism of the effects on proteins, several attempts have been reported. In this review, we would review the attempts from thermodynamic and kinetic viewpoints.

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Nakakido Makoto, Kudou Motonori, Arakawa Tsutomu and Tsumoto Kouhei, To be Excluded or to Bind, that is the Question: Arginine Effects on Proteins, Current Pharmaceutical Biotechnology 2009; 10 (4) . https://dx.doi.org/10.2174/138920109788488824