Mechanisms of Protein Aggregation

John   S.   Philo; Tsutomu      Arakawa

doi:10.2174/138920109788488932

Abstract

Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.

Keywords: Aggregation, self-association, mechanism, nucleation

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